Extended Data Fig. 6: Supporting analyses of HLA-specific and antigen-binding associations.

(a) Summary of four-digit HLA genotype frequencies across both UKB and AOU individuals of NFE/EUR ancestry. The Pearson correlation of the allele frequency is noted. (b) Results of allele-level regression, showing the Z-statistic of the two-sided Wald test for individual HLA class I alleles. (c) Same as (b) but for class II alleles. (d) Annotation of the strongest predicted peptide per HLA allele for class I (top) and class II (bottom). (e) Schematic of logistic regression analyses to assess peptide presentation/binding scores as a predictor of EBV DNAemia. (f) Correspondence between Z-statistic per allele for regression and permutation statistical models for the UKB NFE cohort. The Pearson correlation between Z-statistic of the alleles is noted. (g) Same as in (d) but for the AOU EUR cohort.  The silhouette in panel e was adapted from ref. ¹⁹, Springer Nature Ltd.