Extended Data Fig. 7: Analyses of genetic variation in the EBV genome.
From: Population-scale sequencing resolves determinants of persistent EBV DNA
(a) Summary of 9 selected variants that discriminate between type 1 and type 2 EBV strains. The observed allele frequency for the reference contig (NC_007605; type I EBV) is plotted, and the corresponding type 2 allele is noted in parentheses. (b) The Pearson correlation of the two allele frequencies is noted. (c) Characterization of EBV variants of unknown significance (VUS) from cohorts of nasopharyngeal carcinoma (NPC) tumors55. All but 4 variants were detected at \(\ge \)10% in one or both cohorts. (d) Comparison of predicted peptide presentation strength for all possible peptides and HLA-A/B/C alleles containing one of four VUS from (c). (e) Same as (d) but for class II alleles. For (d) and (e), dotted blue lines reflect the weakest epitope nominated by NetMHC and confirmed to be bound by IEDB for class I and class II.
