Extended Data Fig. 3: Supporting analyses for phenome-wide associations for selected traits.
From: Population-scale sequencing resolves determinants of persistent EBV DNA
(a) Summary of associations between EBV DNAemia and quantitative traits in UKB individuals of broadly non-Finnish European (NFE) ancestry. The dashed line represents the phenome-wide significant P value threshold (3.3 × 10−6). The y-axis is capped at -log10(P) = 50; all associations are plotted (n = 1,931), with those exceeding this threshold plotted at 50. Selected traits are highlighted based on biological interest. Statistical test: Wald test from logistic regression model (two-sided). (b) Focused association summary for two ICD-10 codes. (c) Top UKB neurological associations, sorted by effect size (odds ratio; OR). Traits were filtered for a minimum of 10 cases and a nominal P < 0.05 (logistic regression; two-sided). For (b,c), error bars represent the 95% confidence interval of the OR estimate from either cohort. Dotted lines at OR = 1 represent null associations. Center measurement represents point estimate. Sample size: n = 426,563 UKB NFE individuals; n = 133,578 for AOU European (EUR) ancestry individuals.
