Extended Data Fig. 14: M5 Regulator CRISPRi additional data.
From: Developmental convergence and divergence in human stem cell models of autism
(a) Broad positive correlation between DEGs across targets in NPCs (right) and cNPCs (left) and DEGs in patient-derived organoids across developmental stages. (b) Enrichment of rare genetic variation gene-lists in the differentially expressed genes of each target. Significance derived from two-sided Fishers exact tests. (c) Jaccard Index of DEG overlaps for each target. (d) Meta-analysis significant genes across targets show enrichment in several hCO-derived regulatory modules. Significance derived from two-sided Fishers exact tests.
