Extended Data Fig. 5: Comparison of the binding sites of different PIPs.
From: Regulation of STING activation by phosphoinositide and cholesterol
(a) Cryo-EM map and atomic model of the STING high-order oligomer in the presence of cGAMP, PI4P and STG2. PI4P and CHS have very weak density and therefore not included in the atomic model. (b) Comparison of the density of PIPs in the four structures presented in this study. The thresholds of the cryo-EM maps were set such that the sidechain of H16 is covered at similar levels in the four structures. It is clear that the density for PI4P is much weaker than PI(3,5)P2 and PI(4,5)P2 in the three other structures.
