Fig. 3: Contrasting intermediate states of MOR–Gi1 versus NTSR1–Gi1 GTP-induced activation.
From: Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity
a, Populations and structures for the intermediate states observed in the GTP-induced activation of the MOR–Gi1–lofentanil complex. b, Populations and structures for the intermediate states observed in the GTP-induced activation of the NTSR1–Gi1 complex. c, Sequences of the NTSR1 and MOR ICL2 region and alignment of the active-state receptor structure of MOR (green) with the C-closed-GTP state of NTSR1, highlighting ICL2 differences. d, Alignment of the active-state receptor structure of MOR with the NC-closed-GTP state of NTSR1, highlighting the C-closed-GTP state of NTSR1 and differences in ICL2. e, Alignment of the active-state receptor structure of MOR with the NC-closed-GTP state of NTSR1, highlighting the C-closed-GTP state of NTSR1 and differences in TM5–ICL3–TM6, together with the sequence of the TM5 and TM6 regions of NTSR1 and MOR.
