Fig. 4: Structure of the post-cleavage cap-snatching complex.
From: Mechanism of co-transcriptional cap snatching by influenza polymerase
a, Overall structure of the post-cleavage FluPol–Pol II–DISF elongation complex in cartoon representation except for Pol II, which is shown as surface. b, Comparison of the RNA path in FluPol between pre and post-cleavage complex. Proteins are shown as transparent surfaces and the RNA is shown as ribbon tracing of the backbone. FluPol polymerase active site Mg2+ atoms are modelled on the basis of the FluPol elongation complex14. Parts of FluPol were removed for clarity. c, Comparison of the FluPol polymerase active site conformations in the post-cleavage (pink) and pre-initiation (Protein Data Bank (PDB): 6RR7, light purple44) states. Only the priming loop, the viral mRNA and the 3′ vRNA are shown.
