Extended Data Fig. 2: MPOA representations of the stress state of others and allogrooming behavior.
From: Shared neural substrates of prosocial and parenting behaviours
a, Performance of decoders in differentiating between investigation events toward stressed versus unstressed conspecifics in male and female subject animals. b–d, Performance of decoders in discriminating between allogrooming and baseline (b), between allogrooming and investigation toward stressed conspecifics (c), and between allogrooming and self-grooming (d) in male and female subject animals. e, Performance of 4-way decoders in classifying investigation toward stressed conspecifics, allogrooming, self-grooming, and baseline. f, The magnitude of the coefficients of investigation and allogrooming toward stressed conspecifics in generalized linear models between the activities of individual neurons and various types of behaviors (investigation toward unstressed animals, investigation toward stressed conspecifics, allogrooming, self-grooming, and baseline). g, The fraction of cells with significant, positive coefficients for investigation or allogrooming toward stressed conspecifics in the generalized linear models. h, The magnitude of the coefficients of investigation and allogrooming toward stressed conspecifics in linear mixed-effects models of the activities of individual neurons that included various types of behaviors as fixed effects and the identity of the interacting partners as a random effect. i, The fraction of cells with significant, positive coefficients for investigation or allogrooming toward stressed conspecifics in the linear mixed-effects models. j–m, Performance of decoders in discriminating between investigation events toward stressed versus unstressed conspecifics (j), between allogrooming and baseline (k), between allogrooming and investigation toward stressed conspecifics (l), and between allogrooming and self-grooming (m) when using different numbers of randomly sampled cells. n, o, The fraction of cells significantly activated (determined by ROC analysis) during different types of behaviors among all cells (n) or subsets of cells with an auROC value > 0.7 (o). (a-e, g, i, j-o), The center line in the boxplots indicates the median, the box limits indicate the upper and lower quartiles, and the whiskers indicate the range from the minimum to the maximum value. (f, h), The center line in the boxplots indicates the median, the box limits indicate the upper and lower quartiles, and the whiskers indicate data within 1.5× interquartile range. (a-e, f-i), Two-sided Wilcoxon signed-rank test. n = 10 male mice and 11 female mice in (a, g, i, n, o), 9 male mice and 9 female mice in (b-d, e, j-m), 1772 cells from 21 mice (10 male mice and 11 female mice) in (f, h). See Supplementary Table 1 for details of statistical analyses. **P < 0.01. ***P < 0.001. ****P < 0.0001.
