Extended Data Fig. 9: SignalP analysis of the signal peptide region containing the GLP1R p.Pro7Leu variant.
From: Genetic predictors of GLP1 receptor agonist weight loss and side effects
Each plot shows the marginal probabilities for signal peptide regions; the n-terminal region (red), the center hydrophobic region (orange), and the c-terminal region (yellow). The location of the amino acid change is highlighted. The green dashed line indicates the predicted cleavage site (CS). a) Estimated domain probabilities for the wild-type proline variant. b) Estimated domain probability for the mutant leucine variant.
