Fig. 2: Genetic associations with GLP1 medication side effects.
From: Genetic predictors of GLP1 receptor agonist weight loss and side effects
a, Manhattan plot of experiencing moderate-to-severe vomiting while on tirzepatide treatment. SNPs achieving genome-wide significance (P < 5 × 10−8) are highlighted in red. b, Regional plot around the GIPR locus. Colours indicate strength of linkage disequilibrium (r2) relative to the index SNP (rs71338792). Note that the probable causal missense variant, rs1800437, is located within the cluster of significant SNPs and is in very high linkage disequilibrium with the index SNP (r2 = 0.99). Non-coding variants are indicated with plus symbols; coding variants are indicated with multiplication symbols. c, Estimated effect sizes of rs1800437 in the vomiting side effect, partitioned by drug type, for Europeans, Latinos and a fixed effect meta-analysis. Circles, point estimates; horizontal bars, 95% confidence intervals (CI). OR, odds ratio.
