Supplementary Figure 10: Editing yields for the editing of a 5′ UAG codon in the ORF of GAPDH in HeLa cells with ASO v25 containing a chemically unmodified versus modified ADAR-recruiting domain.
From: Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Here, an ASO v25 with a chemically unmodified ADAR-recruiting domain (unmod R/G), was compared to an ASO of the same sequence with addititional chemical modifiaction (all pyrimidine nucleotides in the ADAR-recruiting domain are backbone 2’-O-methylated). ASOs were transfected in HeLa cells. Data are shown as the mean±SD, N=3 independent experiments.
