Supplementary Figure 3: Systemic versus intraventricular delivery of CAR T cells against tumors in the brain.
From: CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
(a) Schematic representation of experimental design in which 5 × 103 U87vIII cells were implanted orthotopically into the brains (intracebral, IC) of NSG mice and treated with either intravenous (IV) or intraventricular (IVT) CAR T cells (1 × 106 transduced cells). (b) Survival plot of mice treated by CART-EGFRvIII, grouped by route-of-delivery, compared to treatment with UTD cells, n = 5 animals per group.
