Supplementary Figure 9: Modeling of NS3a:danoprevir and NS3a:grazoprevir occupancies.
From: Multi-input chemical control of protein dimerization for programming graded cellular responses
The fraction of NS3a bound to danoprevir (orange, left axis) and the fraction of NS3a bound to grazoprevir (yellow, right axis) was calculated for a constant concentration of 100 nM danoprevir, with increasing concentrations of grazoprevir. The vertical gray lines mark the grazoprevir concentrations used for the experiments in Fig. 4, Supplementary Fig. 11, and Supplementary Fig. 12.
