Supplementary Figure 6: Nanopore raw signal of the C9orf72 STR in NA12878 cells.
From: Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing
Compound multi signal HMM alignment of publicly available raw traces from two template and eight complement reads from the NA12878 cell line shows matching signal pattern in all reads [Nature Biotechnology, Jain, Koren et al., 2018]. Displayed are the current measurements as dots and the model signal as black line. Blue dots indicate current measurements identified as prefix or suffix (see Supplementary Fig. 1). Red dots indicate raw current measurements identified by STRique as belonging to the C9orf72-(G4C2)n-STR. STRique detects in this case five (G4C2)-repeats.
