Extended Data Fig. 7: Comparative gene expression analysis of bladder tissues 12 days. | Nature Biotechnology

Extended Data Fig. 7: Comparative gene expression analysis of bladder tissues 12 days.

From: A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer

Extended Data Fig. 7: Comparative gene expression analysis of bladder tissues 12 days.

a, Gene categories regulated by E. coli 536 supernatant (SN) compared to Sham. Predominance of cancer-related genes including bladder cancer genes. b, Cancer functions regulated in the E. coli 536 SN treated mice compared to Sham. The majority were down-regulated. c, Heat-map comparing E. coli 536 SN- or recombinant Lon protease (rLon)-treated mice to Sham (cut off FC ≥ 2, P < 0.05 compared to healthy bladders). d, Principle Component Analysis (PCA) plot showing a shift from disease (Sham) to a healthier phenotype (Healthy), which was more pronounced in rLon treated than in E. coli 536 SN treated mice. e, A similar trend was seen by the biofunctions analysis, illustrating the comparison of rLon treated mice and E. coli 536 SN treated mice. Data from rLon treated mice compared to Sham are also included in main Fig. 5.

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