Extended Data Fig. 6: Analysis of chromflock structures generated using both GPSeq and Hi-C data (HG structures).
From: GPSeq reveals the radial organization of chromatin in the cell nucleus
(a) Distribution of the average distance from the modeled nuclear surface of 1 Mb beads in 10,000 HG structures per chromosome. chr9:22 and chr22:9 are the derivative chromosomes of the t(9;22)(q34;q11.2) translocation. (b) Correlation between the average chromosome distance from the modeled nuclear surface in HG structures and chromosome size in base-pairs (bp). Each dot corresponds to one chromosome. (c) Distance matrix heatmap. The upper triangle shows the inter-bead 3D distances in HG structures. The bottom triangle shows the KR-normalized Hi-C contact frequency matrix, with each element raised to the power of –0.25. The reported correlation coefficients are for 1 Mb resolution, while the plot shows averaged values over 10 Mb genomic windows for simplicity. (d) Correlation between the distance from the modeled nuclear surface position of 1 Mb beads in HG structures, and the log2 GPSeq score of the corresponding windows. n = 2,627 genomic windows (points) were analyzed.
