Extended Data Fig. 8: Radial organization of A/B compartments and subcompartments in chromflock structures.

(a) Examples of A/B arrangement in chromflock structures (1 Mb resolution) built using both GPSeq and Hi-C (HG) or only Hi-C (H) data. In all the structures, each bead represents a single 1 Mb genomic window. Elements connecting the beads are shown in yellow. The modeled nuclear surface is shown in grey. (b) Distribution of the difference in the median distance from the modeled nuclear surface of 1 Mb A-compartment beads vs. B-compartment beads per structure (n = 10,000) per chromosome (either for the HG or the H structures). Grey shades are used to visually distinguish different chromosomes. Sample size information is available in Source Data. (c) Examples of subcompartment arrangement in three out of 1,000 HG structures at 100 kb resolution. In all the structures, each bead represents a single 100 kb genomic window. The modeled nuclear surface is shown in grey. (d) Distribution of the distance to the modeled nuclear surface of the 100 kb beads belonging to different A/B subcompartments in 1,000 HG structures. n, number of beads belonging to each A/B subcompartment pooled from all the 1,000 structures. In all the violin plots in the figure, each box spans from the 25^th to the 75^th percentile, whiskers extend from –1.5×IQR to +1.5×IQR from the closest quartile, where IQR is the inter-quartile range.