Extended Data Fig. 9: Polarity and orientation of A1 and B3 subcompartments in 100 kb-resolution chromflock structures.

(a) Examples of possible arrangements of two subcompartments (red and blue) and their corresponding polarity score, p (see Supplementary Methods for how p is calculated). (b) Same as in (a), but for the orientation score, o. (c) Distributions of polarity scores in structures built using GPSeq and Hi-C data (HG), separately for each chromosome. (d) Same as in (c), but for orientation scores. (e, f) Same as in (c, d), respectively, but for structures built using only Hi-C data (H). Each boxplot in (c-f) corresponds to n = 1,000 structures. chr9:22 and chr22:9 are the derivative chromosomes of the t(9;22)(q34;q11.2) translocation. Box plots span from the 25th to the 75th percentile and whiskers extend from –1.5 × IQR to +1.5 × IQR from the closest quartile, where IQR is the inter-quartile range.