Extended Data Fig. 8: Potential transcription factor binding sites that can be created with SPACE. | Nature Biotechnology

Extended Data Fig. 8: Potential transcription factor binding sites that can be created with SPACE.

From: A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

Extended Data Fig. 8

Bar plot showing computationally determined number of genes (y-axis) that could be targeted by SPACE to install 1–5 (or more) transcription factor binding sites (x-axis) in proximity of the transcription start site of coding genes in the human genome for 10 transcription factors. Sites were filtered to contain a preferential SPACE editing window (C3-C4-A5) and a canonical NGG PAM (Methods).

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