Extended Data Fig. 6: On-target C-to-T, A-to-G, and dual editing, and indel frequencies induced by coexpression of miniABEmax-V82G and Target-AID compared with SPACE.
From: A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
a, Bar and dot plots showing mean sum of allele frequencies of all edited alleles with A-to-G only, C-to-T only, and concurrent A-to-G and C-to-T editing resulting from coexpression of miniABEmax-V82G and Target-AID (ABE & CBE mix, grey) or SPACE (green) with 28 gRNAs (n = 4). Single dots represent individual replicates. Error bars represent the standard deviation (SD). Data are from the same experiment as shown in Extended Data Fig. 5. b, Dot plots showing on-target DNA indel frequencies of nCas9 (Control, black), coexpression of miniABEmax-V82G and Target-AID (ABE & CBE mix, grey) and SPACE (green) with 28 gRNAs (n = 4). Single dots represent individual replicates. Data are from the same experiment as shown in Extended Data Fig. 5.
