Extended Data Fig. 8: Functional annotation of gut microbiome species.
From: A unified catalog of 204,938 reference genomes from the human gut microbiome
a, Functional profiles of the UHGG species pan-genomes (rows) according to 363 KEGG modules (columns). Numbers of genes matching each module were normalized to centered log ratios after imputing values with zero counts. Species are colored according to phylum. KEGG modules and species were hierarchically clustered using the Ward’s criterion method. b, Proportion of each species pan-genome, partitioned by phylum, without any assignment to the eggNOG, InterPro, COG or KEGG databases (left). Proportion of the pan-genome with a match to the carbohydrate-active enzymes (CAZy) database (right). Sample size (number of species) of each phylum is indicated in parentheses (n = 4,644 total species). Box lengths represent the IQR of the data, and the whiskers the lowest and highest values within 1.5 times the IQR from the first and third quartiles, respectively.
