Extended Data Fig. 9: Whole exome sequencing identifies de novo mutations in RAFi/MEKi-resistant clones. | Nature Biotechnology

Extended Data Fig. 9: Whole exome sequencing identifies de novo mutations in RAFi/MEKi-resistant clones.

From: Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters

Extended Data Fig. 9: Whole exome sequencing identifies de novo mutations in RAFi/MEKi-resistant clones.

a, Total number of detected variants per sample. b, Summary of variant classification visualized as box plots; n = 5 (5 individual cell clones); box displays median with 25th and 75th quartile, whiskers correspond to minimum and maximum values; values correspond to the data in Supplementary Fig. 9a. c, Overview of SNV classes. d, Read tracks of the Kras locus at codon 12 for clones BC14559TN and BC14559R. The KrasG12R mutation was exclusively identified in BC14559R.

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