A new dimension for analyzing mass spectrometry data allows rapid quantification of up to 70% more peptides.
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References
Messner, C. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-021-00860-4 (2021).
Washburn, M. P., Wolters, D. & Yates, J. R. III Nat. Biotechnol. 19, 242–247 (2001).
Muntel, J., Gandhi, T., Verbeke, L. & Bernhardt, O. M. Mol. Omics 15, 348–360 (2019).
Sham, P. C. & Purcell, S. M. Nat. Rev. Genet. 15, 335–346 (2014).
Moseley, M. A. et al. J. Proteome Res. 17, 770–779 (2018).
Demichev, V., Messner, C. B., Vernardis, S. I., Lilley, K. S. & Ralser, M. Nat. Methods 17, 41–44 (2020).
Battle, A. et al. Science 347, 664–667 (2015).
Slavov, N. Science 367, 512–513 (2020).
Specht, H. et al. Genome Biol. 22, 50 (2021).
Meyer, J. G., Niemi, N. M., Pagliarini, D. J. & Coon, J. J. Nat. Methods 17, 1222–1228 (2020).
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Slavov, N. Increasing proteomics throughput. Nat Biotechnol 39, 809–810 (2021). https://doi.org/10.1038/s41587-021-00881-z
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DOI: https://doi.org/10.1038/s41587-021-00881-z
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