Extended Data Fig. 2: Cell composition in children and adults and ACE2 expression. | Nature Biotechnology

Extended Data Fig. 2: Cell composition in children and adults and ACE2 expression.

From: Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

Extended Data Fig. 2: Cell composition in children and adults and ACE2 expression.

(a) Distribution of all cell types/ states in children and adults separated by SARS-CoV-2 infection status. Given are percentages of the total number of cells. Comparisons by Kruskal-Wallis test followed by Dunn’s two-sided post hoc comparison (*significance of comparison between children and adults, P < 0.05; Neutrophil: 5.54E-07, mDC: 1.47E-03, rMa: 3.71E-03, NK: 8.73E-03, p_NKT: 4.96E-02, ag_T: 6.09E-04, Treg: 8.50E-03, DNT: 1.62E-04, CD8_Tm: 1.97E-04, IL17A_CD8: 3.05E-04, IL17A_CD4: 2.68E-03, CTL2: 1.83E-05, CTL1: 3.60E-03, Plasma_cell: 1.83E-05, B_cell: 2.45E-03, immune_total: 1.61E-06, Basal: 6.96E-05, Cil_diff: 2.35E-03, Cil_acute_phase: 8.92E-06, Ciliated: 9.18E-07, Sec_diff: 5.09E-03). (b) Violin plots show distribution of the SARS-CoV-2 entry receptor ACE2 expression and the gene expression of associated proteases in epithelial cells of children and adults either with (n=24 children, n=21 adults) or without SARS-CoV-2 infection (n=18 children, n=23 adults). Plots show median. No significant differences were observed.

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