Extended Data Fig. 2: Control over backbone stereochemistry enhances ADAR1-mediated RNA editing of exogenous and endogenous transcripts. | Nature Biotechnology

Extended Data Fig. 2: Control over backbone stereochemistry enhances ADAR1-mediated RNA editing of exogenous and endogenous transcripts.

From: Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

Extended Data Fig. 2: Control over backbone stereochemistry enhances ADAR1-mediated RNA editing of exogenous and endogenous transcripts.

a, Schematic representation of AIMers targeting ACTB. Fold change in relative luciferase expression at increasing concentrations of the indicated AIMers. Data are represented as mean ± s.e.m., n = 2. b, Traces from Sanger sequencing reactions from RPE cells treated with no AIMer (mock, left) or ACTB-33 (right). The red arrow indicates the site of A-to-I (G) editing.

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