Extended Data Fig. 2: DddA6 is compatible with split-G1333 and split-G1397 DdCBE orientations. | Nature Biotechnology

Extended Data Fig. 2: DddA6 is compatible with split-G1333 and split-G1397 DdCBE orientations.

From: CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Extended Data Fig. 2: DddA6 is compatible with split-G1333 and split-G1397 DdCBE orientations.

a-d, Mitochondrial base editing efficiencies of HEK293T cells treated with (a) ND1.1-DdCBE, (b) ND1.2-DdCBE, (c) ND2-DdCBE and (d) ND4-DdCBE. Target spacing regions and split DddA orientations are shown above each plot. Values and error bars reflect the mean±s.d of n = 3 independent biological replicates.

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