Extended Data Fig. 3: Binding models learned through joint analysis of CAP-SELEX and HT-SELEX data. | Nature Biotechnology

Extended Data Fig. 3: Binding models learned through joint analysis of CAP-SELEX and HT-SELEX data.

From: Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning

Extended Data Fig. 3: Binding models learned through joint analysis of CAP-SELEX and HT-SELEX data.

Models are displayed as in Extended Data Figure 2c. Red and blue arrows indicate the configurations identified as cooperative in the original analysis of each dataset. These configurations (which correspond to the red line in Extended Data Figure 2e) were identified by aligning the inferred monomer binding modes to the position-probability matrices reported in the original study and selecting the configuration that minimizes the KL divergence.

Back to article page