Fig. 4: Analytical validation and comparison of available T cell assays.
From: Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR
a, Comparison of the various assays used to determine T cell response to spike peptides. Total P/N = total positives/negatives (that is, above or below threshold, respectively). TP/TN = true positives/negatives (that is, correctly above or below threshold, respectively, according to the participant’s COVID-19/vaccination status). FP/FN = false positives/negatives. Sensitivity = true positives/(true positives + false negatives). Specificity = true negatives/(true negatives + false positives). Diagnostic accuracy = (true positives + true negatives)/all samples). b, ROC curves, AUC values and associated 95% confidence intervals for each assay.
