Extended Data Fig. 9: CD organoids resemble the IMCD with respect to IC differentiation. | Nature Biotechnology

Extended Data Fig. 9: CD organoids resemble the IMCD with respect to IC differentiation.

From: Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types

Extended Data Fig. 9

a, Region-specific expression from the mouse CD42 revealed absence of IC-related genes (Atp6v1g3, Foxi1, and Tfcp2l1) in the IMCD, and markers of transitional PC/ICs were either reduced (Sec23b, Parm1) or absent (Syt7) in the IMCD. n = 3 independent biological replicates per timepoint. b, Expression in day 18 CD organoids was comparable to the mouse IMCD, with absence of ATP6V1G3 and FOXI1 and low level of TFCP2L1. The transitional cell gene SEC23B was expressed throughout the principal clusters, but neither PARM1 nor SYT7 were abundant. Column and error bars represent mean and standard deviation, respectively.

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