Extended Data Fig. 9: Effect of gene dosage on transcription in excitatory mouse cortical neurons.
From: A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH
(a) Violin-plot (center dot – median; gray bar – quartiles) of RNA transcripts detected by seqFISH+ RNA imaging, corresponding to genes traced by seqFISH+ DNA imaging (excitatory neurons - n = 458 cells across 3 experiments). RNA counts are stratified by gene dosage, delineated by mouse chromosome. Statistical significance and p-values evaluated by two-sample pairwise t-tests are labeled above, comparing 2N vs 3N nuclei of a given chromosome.
