Extended Data Fig. 2: MuSK-CAAR directs specific cytolysis of anti-MuSK B-cells. | Nature Biotechnology

Extended Data Fig. 2: MuSK-CAAR directs specific cytolysis of anti-MuSK B-cells.

From: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Extended Data Fig. 2: MuSK-CAAR directs specific cytolysis of anti-MuSK B-cells.The alternative text for this image may have been generated using AI.

NTD-T cells, anti-CD19 CART (CART-19), and MuSK-CAART were co-incubated with Nalm-6 control, Nalm-6 3−28 (anti-MuSK Ig2), and Nalm-6 4A3 (anti-MuSK Fz) cell lines at indicated E:T ratios. Cytotoxicity was evaluated at 24 hours using a luciferase-based assay. Error bars indicate mean ± standard deviation of triplicates.

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