Extended Data Fig. 9: Additional single-cell epitope analysis results for EPCAM and CD24 in ovarian cancer.
From: Single-cell mapping of combinatorial target antigens for CAR switches using logic gates
a, Distribution of EPCAM and CD24 protein expression levels broken down by annotated cell type. Log2 fold changes comparing CITE-seq ADT signals from targeting antibodies versus isotype controls were computed and are displayed in each cell type. b, Clustering and cell-type mapping of tumor and tumor-resident normal cells based on the CITE-seq transcriptome. c, Single-cell maps, as in (b), overlaid with mRNA expression levels retrieved from CITEseq. d, Single-cell maps, as in (b), overlaid with protein expression levels retrieved from CITE-seq. e, Single-cell maps, as in (b), overlaid with the mRNA expression status indicating cells with both EPCAM and CD24 (brown), only EPCAM (light blue), only CD24 (light red), or none (gray). f, Single-cell maps, as in (b), overlaid with the epitope expression status indicating cells with both EPCAM and CD24 (brown), only EPCAM (light blue), only CD24 (light red), or none (gray).
