Extended Data Fig. 4: Regulatory elements show differences in motif distribution and strength.

(a) Left: Bar plots representing the genome wide distribution of regulatory elements (top), or accessible regulatory elements (bottom). Right top and bottom; per tested transcription factor: Bar plots representing the distribution of regulatory elements at sites with the respective binding motif of each factor (first bar plot), at sites with the motif that are accessible (second bar plot), at sites with the motif and detected high confidence \(K_d^{App}\) (bound, third bar plot) and at sites with the motif that are accessible and detected high confidence \(K_d^{App}\) for the respective transcription factor. (b) Box plots representing z-scores of motif strength for the respective transcription factors per regulatory element. Numbers at the bottom of each plot represent the number of sites in each group. p-values of a two-sided Wilcoxon test are reported. Box plots were drawn with the center line as the median, the hinges as the first and third quartiles, and with the whiskers extending to the lowest and highest values that were within 1.5 × interquartile range.