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Drug delivery

CRISPR editing in the lung with novel lipids

Nature Biotechnology volume 41, pages 1387–1388 (2023)Cite this article

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CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles.

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Fig. 1: Overview of LNP formulation screening process.

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Author notes

  1. These authors contributed equally: Uri Elia, Edo Kon

Authors and Affiliations

  1. Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    Uri Elia, Edo Kon & Dan Peer

  2. Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel

    Uri Elia, Edo Kon & Dan Peer

  3. Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel

    Uri Elia, Edo Kon & Dan Peer

  4. Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel

    Uri Elia, Edo Kon & Dan Peer

  5. Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel

    Uri Elia

Authors
  1. Uri Elia
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  2. Edo Kon
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  3. Dan Peer
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Corresponding author

Correspondence to Dan Peer.

Ethics declarations

Competing interests

D.P. receives licensing fees (to patents on which he was an inventor) from, invested in, consults for (or is on scientific advisory boards or boards of directors of), lectured to (and received a fee from) or conducts sponsored research at Tel Aviv University for the following entities: ART Biosciences, BioNTech SE, Eleven Therapeutics, Kernal Biologics, Merck, Newphase Ltd., NeoVac Ltd., RiboX Therapeutics, Roche, SirTLabs Corporation and Teva Pharmaceuticals Inc. The other authors declare no competing interests.

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Elia, U., Kon, E. & Peer, D. CRISPR editing in the lung with novel lipids. Nat Biotechnol 41, 1387–1388 (2023). https://doi.org/10.1038/s41587-023-01744-5

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  • DOI: https://doi.org/10.1038/s41587-023-01744-5

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