Extended Data Fig. 6: Whole organism miRNA aging trajectory clustering and enriched pathways of mRNAs targeted by local aging miRNAs. | Nature Biotechnology

Extended Data Fig. 6: Whole organism miRNA aging trajectory clustering and enriched pathways of mRNAs targeted by local aging miRNAs.

From: Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

Extended Data Fig. 6

(A) Fuzzy c-means organism-wide z-scored trajectory clustering for all miRNAs in all tissues into 20 clusters. (B) Top 20 non-disease-related locally enriched significant pathways overlapping between tissues and mRNA targets identified via negative correlation with the aging miRNA set (r > 0.5, with age) in each individual tissue. (C) Top 25 non-disease-related locally enriched significant pathways overlapping between tissues. mRNA targets identified via negative correlation with miRNA correlated negatively with aging (r < -0.5) in each individual tissue (identified via overrepresentation analysis, hypergeometric test, two-sided, adjustment FDR, t-test < 0.001).

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