Fig. 4: Mitochondrial C-to-T base editing by nickase combined with rAPOBEC1 and UGI.
From: Strand-selective base editing of human mitochondrial DNA using mitoBEs
a–c, The editing efficiency of mitoCBEs at MT-ND4 (a), MT-RNR2 site 3 (b) and MT-RNR2 site 1 (c). The green rounded rectangle represents rAPOBEC1, the brown rounded rectangle represents UGI, the purple rounded rectangle represents MutH and the gray rectangle represents TALE. d–f, Comparison of the editing profiles of mitoCBEs and DdCBEs at MT-ND4 (d), MT-RNR2 site 3 (e) and MT-RNR2 site 1 (f). For a–f, data are presented as mean values ±s.d. of n = 3 independent biological replicates.
