Extended Data Fig. 3: mitoABEMutH un-enable efficient editing on non-GATC sites.
From: Strand-selective base editing of human mitochondrial DNA using mitoBEs
The editing efficiencies of target regions at the 5’-GATA-3’ (a), 5’-GATG-3’ (b) and 5’-GATT-3’ (c) positions with different mitoABEMutH orientations and distances to 5’-GATD-3’. a-c, the mean values from n = 3 biologically independent replicates are shown. In a-c, the purple rounded rectangle represents MutH, and the gray rectangle represents TALE.
