Extended Data Fig. 7: Fate annotation in direct reprogramming. | Nature Biotechnology

Extended Data Fig. 7: Fate annotation in direct reprogramming.

From: Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes

Extended Data Fig. 7

(a) UMAPs with ‘reprogrammed’, ‘dead-end’ and ‘transition’ fate information projected. Fate cells (Days 12 and 21) were re-clustered and annotated with one of the three fates based on marker gene expression/accessibility, in both modalities independently. (b) Clone-cell embedding UMAPs with expression and accessibility information for key marker genes projected. (c) UMAPs with expression and accessibility information of key dead-end marker genes projected. (d) UMAPs for individual modalities with reprogrammed and dead-end fate information projected. (e,f) Contour plots showing longitudinal tracking of cell fates enabled by CellTag-multi, independently for both scRNA and scATAC.

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