Extended Data Fig. 9: Analysis of the impact of TP53 mutations in non-cancerous MMNK1 cells. | Nature Biotechnology

Extended Data Fig. 9: Analysis of the impact of TP53 mutations in non-cancerous MMNK1 cells.

From: Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells

Extended Data Fig. 9

We introduced various TP53 mutations to MMNK1 cells using CRISPR base editors and subsequently cultured the cells under media containing nutlin-3a. Analysis of the resulting population revealed no growth advantage for cells with TP53 mutations compared to wild-type cells. N = 2 biologically independent cells. P = 0.14, 0.85, 0.78, 0.34; two-sided t-test.

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