Extended Data Fig. 10: Single-cell genotyping of SF3B1 gene using TISCC-seq.

We used the CRISPR base editor to introduce various mutations in SF3B1 in K562 cells and genotyped them using TISCC-seq. (a) Transcript structure of SF3B1. (b) Result of single-cell genotype of SF3B1. (c) Gene expression profile based on SF3B1 mutations.