Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News Feature
  • Published:

The glue degraders

Nature Biotechnology volume 42, pages 546–550 (2024)Cite this article

Companies are hoping to discover small molecules that remove undruggable proteins. It won’t be easy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Molecular glue degraders.

SEED Therapeutics

References

  1. Ting, P. Y. et al. Blood 142(Suppl. 1), 2 (2023).

    Article  Google Scholar 

  2. Schreiber, S. L. Cell 70, 365–368 (1992).

    Article  CAS  PubMed  Google Scholar 

  3. Liu, J. et al. Cell 66, 807–815 (1991).

    Article  CAS  PubMed  Google Scholar 

  4. Tan, X. et al. Nature 446, 640–645 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Rui, H., Ashton, K. S., Min, J., Wang, C. & Potts, P. R. RSC Chem. Biol. 4, 192–215 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ito, T. et al. Science 327, 1345–1350 (2010).

    Article  CAS  PubMed  Google Scholar 

  7. Krönke, J. et al. Science 343, 301–305 (2014).

    Article  PubMed  Google Scholar 

  8. Lu, G. et al. Science 343, 305–309 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Gandhi, A. K. et al. Br. J. Haematol. 164, 811–821 (2014).

    Article  CAS  PubMed  Google Scholar 

  10. Neomorph. Guggenheim 2022 Targeted Protein Degradation Day, https://kvgo.com/guggenheim/neomorph-march-2022 (2022).

  11. Han, T. et al. Science 356, eaal3755 (2017).

    Article  PubMed  Google Scholar 

  12. Słabicki, M. et al. Nature 585, 293–297 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Garber, K. Nat. Biotechnol. 40, 12–16 (2022).

    Article  CAS  PubMed  Google Scholar 

  14. Mayor-Ruiz, C. et al. Nat. Chem. Biol. 16, 1199–1207 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Huang, L. et al. Science 286, 1321–1326 (1999).

    Article  CAS  PubMed  Google Scholar 

  16. Cao, S. et al. Nat. Commun. 13, 815 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Dana-Farber TPD. Ning Zheng - Dana-Farber Targeted Degradation Webinar Series, https://www.youtube.com/watch?v=f0YYXe18nuA (2022).

  18. Peterson, A. A. & Liu, D. R. Nat. Rev. Drug Discov. 22, 699–722 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Mason, J. W. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01458-4 (2024).

Download references

Author information

Authors and Affiliations

  1. Ann Arbor, MI, USA

    Ken Garber

Authors
  1. Ken Garber
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Garber, K. The glue degraders. Nat Biotechnol 42, 546–550 (2024). https://doi.org/10.1038/s41587-024-02164-9

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41587-024-02164-9

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing