Extended Data Fig. 5: Enrichment analyses reveal up-regulated pathways in the initial stage of psoriasis pathogenesis.
From: Therapeutic application of circular RNA aptamers in a mouse model of psoriasis
(a) Schematic of clustering the fast-responding inflammatory factors including PKR. 787 DEGs are defined as over threefold up-regulation at D1 compared to D0 in two biological repeats. All DEGs are performed the KEGG pathway enrichment analysis. (b) The KEGG analyses of 151 genes from Cluster 1. (c) A short list of the most enriched genes of Cluster 1 which belong to the IFNα signaling pathways and the dsRNA-sensors related genes. (d)-(h) The enriched KEGG pathways of genes from the other 5 clusters of distinct gene expression patterns in IMQ-induced psoriasis mice model. b, d, e, f, g, h: all pathways are selected according p.adjust < 0.05 and the pathways related to viral or bacterial infection are not shown in Cluster 1.
