Extended Data Fig. 7: Using longitudinal human metagenomes to determine Syntracker’s performance.
From: Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution
a. Representative synteny-based analyses of B. fragilis strains in longitudinal metagenomic samples, obtained from the same host (cyan) and different hosts (pink), using 200 and 40 regions/pairwise-comparison. Dashed red lines represent the APSS threshold differentiating between strains residing in the same host and strains residing in different hosts, as calculated in B. b. ROC plots of the same analyses shown in A. Red dots correspond to the Youden point and give the APSS score that yields the optimal combination of specificity and sensitivity. c. The mean specificity and sensitivity of the synteny approach, calculated at different numbers of regions/pairwise-comparison. R/P- regions/pairwise comparison, PW - pairwise.
