Fig. 4: Combined synteny-based and SNP-based analysis of human gut microbiome reveals patterns of within-species genomic diversity.
From: Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution
a, Synteny-based (APSS) and SNP-based (popANI) strain similarities in human gut metagenomes collected in Gabon, Germany and Vietnam. Dots represent pairwise comparisons within a species. Dots are colored when they are in the top 5% most similar: blue by inStrain, red by SynTracker and purple by both (all others are gray). Density plots show the distribution of scores for each tool. b, Species showing enrichment of SNPs or structural differences. Points represent species. The x axis shows the ratio between the enrichment of each species (that is, the hypergeometric P value) in the most similar 5% of the comparisons by tool. Right, species enriched in SNPs; left, species enriched in structural differences. The y axis indicates the degree of enrichment.
