Extended Data Fig. 9: Contribution and lineage distribution of human cells in the bone marrow, spleen, thymus and peripheral blood of cohort 4–7 mice receiving cells differentiated under protocol 3.
(a) Paired samples of peripheral blood analyzed at 12 (PB12) and 16 weeks (PB16) in MLE mice. (b) Bone marrow engraftment in transplanted mice stratified by recipient sex. RM TOM cells, Female vs Male mice, P = 0.0012; Female MLE vs Male MLE, P = 0.0427; PB5.1, Female vs Male mice, P = 0.0253; PB1.1 BFP and PB10.5, no significant gender differences. One-way ANOVA (Kruskal-Wallis test) with Dunn’s multiple comparisons test. (c) Bone marrow and (d) spleen lineage distribution in MLE mice in cohort 4–7. (e) T cell subsets and B cells in mediastinal lymphoid tissue, comprising thymus and lymph node tissue in MLE mice in cohort 4.
