Extended Data Fig. 7: Editing efficiency induced by engineered TALEDs.
From: Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA
a, Schematic of the constructions of sTALED, sTALED6 and sTALED11 targeting mtDNA. b, A-to-G editing frequencies induced by sTALED, sTALED6 and sTALED11 at the ND5.1 and ND5.3 sites in 293FT cells. c, Schematic of the constructions of sTALED, esTALED_V2 and esTALED_V2_dhUNG targeting mtDNA. dhUNG, catalytically dead hUNG. d, A-to-G editing frequencies induced by sTALED, esTALED_V2 and esTALED_V2_dhUNG at the ND1 and ND5.3 sites in 293FT cells. e, Schematic of the constructions of sTALED_G1333 and esTALED_G1333 targeting mtDNA. f, A-to-G editing frequencies induced by sTALED_G1333 and esTALED_G1333 at the ND1, ND5.3 and ND5.3 sites in 293FT cells. For b, d and f, the data are presented as the mean ± s.d. from three independent experiments.
