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Precision neuroscience

Nature Biotechnology volume 43, pages 659–664 (2025)Cite this article

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Developers are recombining or sharpening established drugs, molecules and mechanisms to create a new generation of neurology therapies.

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Fig. 1: Since 2020, only cancer surpasses neurology in overall M&A value.

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  • 21 May 2025

    In the version of the article initially published, the source for the graph used in Fig. 1 was missing and is now restored in the HTML and PDF versions of the article.

References

  1. Harrison, C. Nat. Biotechnol. 43, 287–289 (2025).

    Article  CAS  PubMed  Google Scholar 

  2. McDermott, L. A. et al. Neuron https://doi.org/10.1016/j.neuron.2019.01.047 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Knowland, D. et al. J. Clin. Invest. https://doi.org/10.1172/JCI140311 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Wieskopf, J. S. et al. Sci. Transl. Med. https://doi.org/10.1126/scitranslmed.3009986 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Conaghan, P. et al. In ACR Convergence 2024 https://acrabstracts.org/abstract/levi-04-a-novel-neurotrophin-3-inhibitor-substantially-improves-pain-and-function-without-deleterious-effects-on-joint-structure-in-people-with-knee-osteoarthritis-a-randomized-controlled-phase-ii/ (2024).

  6. Zhang, M. et al. Signal Transduct. Target. Ther. https://doi.org/10.1038/s41392-023-01464-x (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Khairatkar-Joshi, N. & Szallasi, A. Trends Mol. Med. https://doi.org/10.1016/j.molmed.2008.11.004 (2009).

    Article  PubMed  Google Scholar 

  8. Finol-Urdaneta, R. K. et al. Proc. Natl Acad. Sci. USA https://doi.org/10.1073/pnas.2110932119 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Cao, B. et al. Signal Transduct. Target. Ther. https://doi.org/10.1038/s41392-024-01845-w (2024).

  10. Gahr, M., Kratzer, W., Fuchs, M. & Connemann, B. J. et al. Curr. Drug Metab. https://doi.org/10.2174/1389200215666140926155041 (2014).

    Article  PubMed  Google Scholar 

  11. Bremova-Ertl, T. et al. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2310151 (2024).

    Article  PubMed  Google Scholar 

  12. Churchill, G. C., Strupp, M., Galione, A. & Platt, F. M. et al. PLoS One https://doi.org/10.1371/journal.pone.0229585 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Oertel, W. H. et al. Nat. Commun. https://doi.org/10.1038/s41467-024-51502-7 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Al-zharani, M., Hasnain, M. S., Al-Eissa, M. S. & Alqahtani, R. A. et al. J. King Saud Univ. Sci. https://doi.org/10.1016/j.jksus.2024.103513 (2024).

    Article  Google Scholar 

  15. Razavi, R., Khajouei, G., Divsalar, F., Dawi, E. & Amiri, M. et al. Rev. Neurosci. https://doi.org/10.1515/revneuro-2024-0086 (2024).

    Article  Google Scholar 

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  1. London, UK

    Melanie Senior

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  1. Melanie Senior
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Senior, M. Precision neuroscience. Nat Biotechnol 43, 659–664 (2025). https://doi.org/10.1038/s41587-025-02673-1

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