Fig. 3: Disease-critical cells identified by scPRS. | Nature Biotechnology

Fig. 3: Disease-critical cells identified by scPRS.

From: Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases

Fig. 3

a–c, Disease-critical cells identified by scPRS for T2D (a), HCM (b) and AD (c). Left, scATAC-seq or snATAC-seq datasets used by scPRS, along with annotated cell types. Middle, disease-relevant cells prioritized by scPRS (in red). Cell clusters enriched with scPRS-prioritized cells are highlighted in closed curves with corresponding cell type colors. Right, enrichment of scPRS-selected disease cells within each cell type. ORs and P values were determined using a one-sided Fisher’s exact test. Cell type abbreviations: Fibro, fibroblast; LEC, lymphatic endothelial cell; Peri, pericyte; Schw, Schwann cell; SmMus, smooth muscle cell; VEC, vascular endothelial cell. For robustness, small cell clusters with fewer than 150 cells were excluded from analysis and visualization for all diseases.

Back to article page