Fig. 4: JPLE reconstructs RNA-binding specificities for thousands of eukaryotic RBPs. | Nature Biotechnology

Fig. 4: JPLE reconstructs RNA-binding specificities for thousands of eukaryotic RBPs.

From: A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function

Fig. 4

a, The percentage of measured and predicted specificities for RRM- and KH-domain RBPs across 690 species is shown across major eukaryotic clades and for all eukaryotes combined. The proportions of predicted specificities that were identified by AA SID, JPLE or both are indicated. b, Scatter plot displaying the percentage of specificities for RRM- and KH-domain RBPs that were reconstructed by JPLE compared to AA SID with the 70% rule for 49 representative species (listed in c). c, The number of measured and predicted (that is, reconstructed or inferred) RBP specificities in EuPRI for 49 eukaryotes. Newly measured and predicted specificities are differentiated from the measured and predicted motifs available in the 2013 release of the CisBP-RNA database17.

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