Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity.
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M.C. works part-time for Goat’s Eye Consulting; no company mentioned in this story is a client.
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Cully, M. Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets. Nat Biotechnol 43, 1212–1214 (2025). https://doi.org/10.1038/s41587-025-02779-6
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DOI: https://doi.org/10.1038/s41587-025-02779-6
